AutoVectis and both of the 21T FT-ICR MS(s)
Within the last 2 months, AutoVectis has been successfully used to process published data from both of the 21T FT-ICR MS instruments – the world’s largest, (and arguably) most technologically advanced mass spectrometers. You can see the benefits of using AutoVectis to produce absorption mode FT-ICR spectra for analysis was used here and here.
Zoomed negative mode FT-ICR mass spectrum (R~300,000 FWHM, in absorption mode) after direct infusion of J5 LPS. Eight potential isotopic distribution envelopes can be identified in absorption mode in this 4 m/z window; these are denoted, at the m/z of their respective monoisotopic ions, with blue arrows. (Inset) magnified portion of the spectrum showing fine detail (including the magnitude mode and the proposed overlap between isotopologues from envelopes 2 and 5). Fig 3 from Oyler BL, Khan MM, Smith DF, Harberts EM, Kilgour DP, Ernst RK, Cross AS, Goodlett DR. Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate. Journal of The American Society for Mass Spectrometry. 2018 Feb 20:1-9